Interplay between Sleep Disorders and Pain Disorders
Presenting Author(s): Dr. Payman Hajiazim, MDDate and time: 22 Mar 2025 from 14:05 to 15:05
Location: Hawthorn A
Abstract
Sleep Disorders could impact the pain disorders in multiple ways which could impact the pain medications being taken and the management of the chronic pain and its consequences on the mental health. Addressing those issues would be very important; as they are modifiable factors, often with no or limited side effects which is also important in terms of safety of the treatments.
Learning Objectives
1. Describe the physiologic roles of sleep in the pain perception;
2. Describe the shared risk factors of each sleep disorder and the localized/ distributed pain disorders; and
3. Describe the bidirectional effects of each sleep disorder and the localized/ distributed pa;in disorders
Literature References
1- Felicitas A. Huber, Tyler A. Toledo, Garrett Newsom, Jamie L. Rhudy,The relationship between sleep quality and emotional modulation of spinal, supraspinal, and perceptual measures of pain, Biological Psychology, Volume 171, 2022.
2- Colloca, Luana, and others, 'The role of sleep disturbance in endogenous pain modulation through opioidergic, placebo, and positive affective mechanisms', in Luana Colloca, and others (eds), Placebo Effects Through the Lens of Translational Research (New York, 2023; online edn, Oxford Academic, 1 Oct. 2023)
1- Colloca, Luana, and others, 'The role of sleep disturbance in endogenous pain modulation through opioidergic, placebo, and positive affective mechanisms', in Luana Colloca, and others (eds), Placebo Effects Through the Lens of Translational Research (New York, 2023; online edn, Oxford Academic, 1 Oct. 2023)
2-Kaczmarski P, Karuga FF, Szmyd B, Sochal M, Białasiewicz P, Strzelecki D, Gabryelska A. The Role of Inflammation, Hypoxia, and Opioid Receptor Expression in Pain Modulation in Patients Suffering from Obstructive Sleep Apnea. Int J Mol Sci. 2022 Aug 13;23(16):9080.
1- Seminowicz DA, Remeniuk B, Krimmel SR et al (2019) Pain-related nucleus accumbens function: modulation by reward and sleep disruption. Pain 160(5):1196–1207
2- Sardi NF, Lazzarim MK, Guilhen VA et al (2018a) Chronic sleep restriction increases pain sensitivity over time in a periaqueductal gray and nucleus accumbens dependent manner. Neuropharmacology 139:52–601- Parrino L, Ferri R, Bruni O, Terzano MG (2012) Cyclic alternating pattern (CAP): the marker of sleep instability. Sleep Med Rev 6(1):27–45
2- Rizzi M, Sarzi-Puttini P, Atzeni F et al (2004) Cyclic alternating pattern: a new marker of sleep alteration in patients with fibromyalgia? J Rheumatol 31(6):1193–1199
3- Rizzi M, Radovanovic D, Santus P et al (2017) Influence of autonomic nervous system dysfunction in the genesis of sleep disorders in fibromyalgia patients. Clin Exp Rheumatol 35 Suppl 105(3):74–803-
4- Carra MC, Rompre PH, Kato T et al (2011) Sleep bruxism and sleep arousal: an experimental challenge to assess the role of cyclic alternating pattern. J Oral Rehabil 38(9):635–642
1- Karmann AJ, Kundermann B, Lautenbacher S. Schlafentzug und Schmerz : Ein Review der neuesten Literatur [Sleep deprivation and pain: a review of the newest literature]. Schmerz. 2014 Apr;28(2):141-6. German
2- Haack M, Simpson N, Sethna N, Kaur S, Mullington J. Sleep deficiency and chronic pain: potential underlying mechanisms and clinical implications. Neuropsychopharmacology. 2020 Jan;45(1):205-216.
3- Sleep Fragmentation Hypersensitizes Healthy Young Women to Deep and Superficial Experimental Pain, Iacovides, Stella et al. The Journal of Pain, Volume 18, Issue 7, 844 - 854
4 - Rosseland R, Pallesen S, Nordhus IH, Matre D, Blågestad T. Effects of Sleep Fragmentation and Induced Mood on Pain Tolerance and Pain Sensitivity in Young Healthy Adults. Front Psychol. 2018 Oct 31;9:2089.
5- Da Vitoria Lobo, Marlene E.a; Weir, Nickb; Hardowar, Lydiab; Al Ojaimi, Yarab; Madden, Ryana; Gibson, Alexa; Bestall, Samuel M.c; Hirashima, Masanorid; Schaffer, Chris B.e; Donaldson, Lucy F.c; Bates, David O.a,f; Hulse, Richard Philipa,b,*. Hypoxia-induced carbonic anhydrase mediated dorsal horn neuron activation and induction of neuropathic pain. PAIN 163(11):p 2264-2279, November 2022.
6- Kaczmarski P, Karuga FF, Szmyd B, Sochal M, Białasiewicz P, Strzelecki D, Gabryelska A. The Role of Inflammation, Hypoxia, and Opioid Receptor Expression in Pain Modulation in Patients Suffering from Obstructive Sleep Apnea. Int J Mol Sci. 2022 Aug 13;23(16):9080. etc.