How Pain Shapes the Brain: Impact of Childhood Trauma on Suicide Risk
Presenting Author(s): Dr. Gustavo Turecki , MD PhD FRSC
Date and time: 23 Mar 2024 from 10:20 to 11:20
Location: Wildrose Salon C
Learning Objectives
1. Understand how early-life adversity increases risk of suicide;
2. Learn about behavioral mediators of suicide risk; and
3. Learn about brain molecular changes that associate with early-life adversity and suicide risk.
Literature References
1. Turecki G. The molecular bases of the suicidal brain. Nat Rev Neurosci 2014;15(12):802-16. PMID:25354482
2. Turecki, G & Brent, D.A. Suicide and suicidal behaviour. Lancet. 2016 19;387(10024):1227-39. PMID: 26385066
3. Nagy C, Maitra M, Tanti A, […], Mechawar N, Ragoussis J, Turecki G. Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons. Nature Neuroscience 2020;23(6):771-81. PMID: 32341540
4. Labonté B, Abdallah K, Maussion G, [...] Meaney MJ, Mechawar N, Nestler EJ, Turecki G.Regulation of impulsive and aggressive behaviours by a novel lncRNA. Mol Psychiatry. 2021 (8):3751-3764. PMID: 31907380
Abstract
Early-life adversity, including childhood physical and sexual abuse, as well as severe neglect, are important predictors of lifetime suicide risk. Dr. Turecki will present data suggesting that this association is mediated by behavioral and emotional developmental changes. Focusing on genomic adaptations to life experience, he will also discuss molecular mechanisms that may explain these relationships and explain suicide risk in these individuals.