RESIDENT: Antibody-Mediated Encephalitis in Adults: A Review of Clinical Presentation and Course, Treatments, and Future Directions
Presenting Author(s): Dr. Joseph Emerson MarinasCo-Author(s):
Dmitriy MatveychukDate and time:
23 Mar 2019 from 13:50 to 14:10Location: Hawthorn C
- Review the clinical course of selected antibodymediated encephalitides;
- Delineate features that may distinguish antibodymediated encephalitides from primary psychotic disorders; and
- Provide an overview of the current state of research and areas requiring further study.
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Antibody-mediated encephalitides are a group of conditions with neuropsychiatric features that have gained increasing recognition over
the past decades with NMDA receptor encephalitis being one of the most studied. The association of these conditions with tumours and
their possible reversible course have led to interest in early identification and treatment. Further, prominent behavioural and psychotic
features can result in the initial presentation to clinical attention and at times leads to psychiatric admissions. We searched PubMed,
PsycINFO, and Web of Science databases for references published between the years 2000 to 2018 in our literature review. Although
there do not appear to be clinical features that consistently differentiate between antibody-mediated encephalitides and primary
psychiatric disorders at first presentation, the suspicion of autoimmune causes may be guided by monitoring the evolution of patient
symptoms, imaging and cerebrospinal fluid investigations, and other features associated with specific antibody targets. Further study of
the antibody-mediated encephalitides can help direct treatment approaches and further the understanding of this group of conditions.