I trained in medicine at University College Hospital, London, and then in psychiatry at King’s College Hospital. I then came to Oxford to work in the MRC Unit of Clinical Pharmacology under David Grahame-Smith in his laboratory. I studied the basic neuropharmacology of serotonin and its application to clinical psychopharmacology. Since 1983, I have been a MRC Clinical Scientist and Honorary Consultant Psychiatrist in the Department of Psychiatry in Oxford. I was elected to a personal Chair in Psychopharmacology in the University of Oxford in 1997 and to a Fellowship of the UK Academy of Medical Sciences in 2001. I received a Lifetime Achievement Award from the British Association of Psychopharmacology in 2014. My main interests are in the biochemistry and treatment of mood disorders, particularly the pharmacological management of resistant depression. I am a Senior Author of the Shorter Oxford Textbook of Psychiatry - most recent edition 2017.